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For Major Depressive Disorder with Suicidal Thoughts or Actions | SPRAVATO® (esketamine)
Symptoms of
depression
can make you feel
LOST
but you’ve FOUND
a different choice
to turn to.
 
Nasal spray
Taken along with an oral antidepressant:

SPRAVATO® is the first nasal spray medication that treats depressive symptoms in adults with major depressive disorder with suicidal thoughts or actions.

XSymptoms associated with major depressive disorder may include:
  • Depressed mood or feelings of sadness
  • Disrupted sleep
  • Lack of interest or inability to feel pleasure (anhedonia)
  • Feelings of guilt or hopelessness
  • Lack of energy
  • Difficulty concentrating
  • Changes in appetite or weight
  • Slowed thoughts or movements (psychomotor retardation)
  • Restlessness and/or purposeless movements (psychomotor agitation)
  • Suicidal thoughts or actions

SPRAVATO® is not for use as a medicine to prevent or relieve pain (anesthetic). It is not known if SPRAVATO® is safe and effective as an anesthetic medicine.

It is not known if SPRAVATO® is safe and effective for use in preventing suicide or in reducing suicidal thoughts or actions. SPRAVATO® is not for use in place of hospitalization if your healthcare provider determines that hospitalization is needed, even if improvement is experienced after the first dose of SPRAVATO®.

It is not known if SPRAVATO® is safe and effective in children.

Learn more about SPRAVATO® to see if it may be an option for you.

More About SPRAVATO®

Help is available 24/7. If you’re struggling with suicidal thoughts, call the National Suicide Prevention Lifeline: 1-800-273-8255.

Help is available 24/7. If you’re struggling with suicidal thoughts, call the National Suicide Prevention Lifeline: 1-800-273-8255.

English 1-800-273-8255

Español 1-888-628-9454

EnglishNational Suicide Prevention Lifeline

EspañolRed Nacional de Prevención del Suicidio

The National Suicide Prevention Lifeline is a federally funded network of crisis centers committed to suicide prevention.

 
24 Hours

In clinical studies of adults with MDD with suicidal thoughts or actions:

Those who took SPRAVATO® and an oral antidepressant experienced a greater reduction of depressive symptoms at 24 hours compared to those who took a placebo plus an oral antidepressant.*

Responding to SPRAVATO®

*Based on an overall score on a standardized rating scale.

Most common side effects of SPRAVATO®:

Feeling disconnected from yourself, your thoughts, feelings and things around you (dissociation); dizziness; nausea; feeling sleepy (sedation); spinning sensation; decreased feeling of sensitivity (numbness); feeling anxious; lack of energy; increased blood pressure; vomiting; feeling drunk; and feeling very happy or excited.

If these common side effects occur, they usually happen right after taking SPRAVATO® and go away the same day.

These are not all the possible side effects of SPRAVATO®. Learn more about possible side effects here.

Possible Side Effects

SPRAVATO® is only available at certified SPRAVATO® treatment centers under the supervision of a healthcare provider.

Because of the risks for sedation, dissociation, and abuse and misuse, your healthcare provider will enroll you in the SPRAVATO® Risk Evaluation and Mitigation Strategy (REMS) Program. The REMS Program mitigates these risks by ensuring SPRAVATO® is distributed and administered through certified healthcare settings.

What to Expect
Spravato WithMe

Once you and your doctor have decided that SPRAVATO® is right for you

Ask your doctor about enrolling in SPRAVATO withMe—the support program that’s by your side from the start during your treatment journey

Within 24 hours of your enrollment, you’ll be paired with a dedicated SPRAVATO withMe Care Navigator—a mental health professional who is committed to giving you the informational, emotional, and affordability support you need, how you want it. Care Navigators do not provide medical advice. Please ask your doctor any questions you might have about your disease and treatment.

Once you’re enrolled, a Care Navigator will help you and/or your caregiver understand what to expect with your treatment. They’ll also walk you through your insurance coverage, share ways to help you save on SPRAVATO®, and give you encouragement along the way.

Talk to your doctor about enrolling in SPRAVATO withMe.

Treatment & Cost Support

SPRAVATO withMe is limited to education about SPRAVATO®, its administration, and/or the condition it treats. It is not intended to provide medical advice, replace a treatment plan you receive from your doctor or nurse, or serve as a reason for you to start or stay on treatment.

SPRAVATO® works differently than other medications to relieve depressive symptoms.

SPRAVATO® is taken with an oral antidepressant.

How SPRAVATO® Is Different

Frequently Asked Questions

Major depressive disorder is more than just feeling sad; it’s a disease with a variety of symptoms – including depressed or sad mood – that lasts for at least two weeks and significantly affects thoughts, feelings and behavior.

Sometimes, major depressive disorder can cause people to consider self-harm, or even suicide. When a person experiences a sudden worsening of depressive symptoms, or acts on thoughts of self-harm or suicide, a healthcare provider may prescribe SPRAVATO® to reduce their depressive symptoms.

SPRAVATO® (esketamine) CIII nasal spray is the first prescription nasal spray, taken with an oral antidepressant, for:

  • Adults with treatment-resistant depression
  • Depressive symptoms in adults with major depressive disorder with suicidal thoughts or actions

SPRAVATO® is not for use as a medicine to prevent or relieve pain (anesthetic). It is not known if SPRAVATO® is safe and effective as an anesthetic medicine.

It is not known if SPRAVATO® is safe and effective for use in preventing suicide or in reducing suicidal thoughts or actions. SPRAVATO® is not for use in place of hospitalization if your healthcare provider determines that hospitalization is needed, even if improvement is experienced after the first dose of SPRAVATO®.

It is not known if SPRAVATO® is safe and effective in children.

See All Questions