Treatment-Resistant
Depression
MDD with Suicidal
Thoughts or Actions
Ask a Care Navigator about patient support resources. Call 1-844-4S-WITHME (1-844-479-4846), Monday through Friday, from 8:00 AM to 8:00 PM ET.
*In clinical trials of adults who took SPRAVATO® and an oral antidepressant compared to those who received a placebo and an oral antidepressant. Based on an overall score on a standardized rating scale.
†All patients received comprehensive standard of care treatment, including an initial inpatient hospitalization and a newly initiated or optimized oral antidepressant therapy, which was determined by a healthcare provider.
After you and your healthcare provider have decided SPRAVATO® is right for you – and you understand the benefits and risks of SPRAVATO® – you’ll be ready to start planning for treatment.
Do not take SPRAVATO® if you have a blood vessel disease (aneurysm), an abnormal connection between your blood vessels (arteriovenous malformation), a history of bleeding in the brain or if you are allergic to esketamine, ketamine or any of the ingredients in SPRAVATO®. Talk to your healthcare provider to learn more.
Serious side effects include feeling sleepy (sedation), dissociation, abuse, increased risk of suicidal thoughts and behavior, increased blood pressure, problems with thinking clearly and bladder problems. The most commonly observed side effects in adults taking SPRAVATO® and an oral antidepressant were:
Feeling disconnected from yourself, your thoughts, feelings and things around you
X
A healthcare provider will monitor you for at least two hours. Because of possible side effects affecting mental alertness and motor coordination, you won’t be able to drive, operate machinery or do anything where you need to be completely alert until the next day, following a restful sleep. So you’ll need to plan for rides on treatment days.
Has SPRAVATO® made a difference with your depressive symptoms? Share your story with the SHARE Network.
Today’s most commonly used oral antidepressants are thought to treat depression by increasing levels of neurotransmitters (serotonin, norepinephrine and dopamine) in areas of the brain that affect mood.
SPRAVATO® targets the N-methyl-D-aspartate (NMDA) receptor and is believed to work differently than currently available oral antidepressants. The exact way that SPRAVATO® works is unknown.
If you’re having suicidal thoughts, help is available now. Speak to a counselor at the National Suicide Prevention Lifeline. The Lifeline provides free and confidential 24/7 support for people in distress, as well as prevention and crisis resources.
The National Suicide Prevention Lifeline is a federally funded network of crisis centers committed to suicide prevention.
Next:
The SPRAVATO® treatment plan.
A different treatment experience.
