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About SPRAVATO® for Major Depressive Disorder with Suicidal Thoughts or Actions | SPRAVATO® (esketamine)

About SPRAVATO® For depressive symptoms in adults with
MDD with suicidal thoughts or actions

Get to Know SPRAVATO®


Nasal spray you self-administer under the supervision of a healthcare provider.


Greater reduction of depressive symptoms at 24 hours* (compared to those who received a placebo and oral antidepressant).


Only available at a certified SPRAVATO® treatment center.


After you take SPRAVATO®, a healthcare provider will monitor you for at least two hours during the observation period for possible serious side effects, including feeling sleepy (sedation), and feeling disconnected from yourself, your thoughts, feelings and things around you (dissociation), and increased blood pressure. More About Side Effects


Taken with an oral antidepressant.


Patients who stayed on SPRAVATO® continued to improve through Day 25 of treatment during the clinical studies.*


Tell your healthcare provider if you have a history of drug or alcohol abuse.

*In clinical trials of adults who took SPRAVATO® and an oral antidepressant compared to those who received a placebo and an oral antidepressant. Based on an overall score on a standardized rating scale.

All patients received comprehensive standard of care treatment, including an initial inpatient hospitalization and a newly initiated or optimized oral antidepressant therapy, which was determined by a healthcare provider.

SPRAVATO® nasal spray

SPRAVATO® Dosing for MDD with Suicidal Thoughts or Actions

After you and your healthcare provider have decided SPRAVATO® is right for you – and you understand the benefits and risks of SPRAVATO® – you’ll be ready to start planning for treatment.

  • You’ll administer SPRAVATO® nasal spray yourself under the supervision of a healthcare provider in a certified SPRAVATO® treatment center
  • SPRAVATO® is taken twice a week for four weeks, along with an oral antidepressant
  • After four weeks, you and your healthcare provider will determine if continued treatment with SPRAVATO® is necessary

SPRAVATO® Safety & Tolerability

Do not take SPRAVATO® if you have a blood vessel disease (aneurysm), an abnormal connection between your blood vessels (arteriovenous malformation), a history of bleeding in the brain or if you are allergic to esketamine, ketamine or any of the ingredients in SPRAVATO®. Talk to your healthcare provider to learn more.

SPRAVATO® Side Effects

Serious side effects include feeling sleepy (sedation), dissociation, abuse, increased risk of suicidal thoughts and behavior, increased blood pressure, problems with thinking clearly and bladder problems. The most commonly observed side effects in adults taking SPRAVATO® and an oral antidepressant were:

  • Dissociation

    Feeling disconnected from yourself, your thoughts, feelings and things around you


  • Dizziness
  • Nausea
  • Feeling sleepy (sedation)
  • Spinning sensation
  • Decreased feeling of sensitivity (numbness)
  • Feeling anxious
  • Lack of energy
  • Increased blood pressure
  • Vomiting
  • Feeling drunk
  • Feeling very happy or excited

After Treatment

A healthcare provider will monitor you for at least two hours. Because of possible side effects affecting mental alertness and motor coordination, you won’t be able to drive, operate machinery or do anything where you need to be completely alert until the next day, following a restful sleep. So you’ll need to plan for rides on treatment days.

How Is SPRAVATO® Different?

Today’s most commonly used oral antidepressants are thought to treat depression by increasing levels of neurotransmitters (serotonin, norepinephrine and dopamine) in areas of the brain that affect mood.

SPRAVATO® targets the N-methyl-D-aspartate (NMDA) receptor and is believed to work differently than currently available oral antidepressants. The exact way that SPRAVATO® works is unknown.

Suicide Prevention Lifeline

If you’re having suicidal thoughts, help is available now. Speak to a counselor at the National Suicide Prevention Lifeline. The Lifeline provides free and confidential 24/7 support for people in distress, as well as prevention and crisis resources.

The National Suicide Prevention Lifeline is a federally funded network of crisis centers committed to suicide prevention.


Preparing for Treatment

The SPRAVATO® treatment plan. 
A different treatment experience.