Preparing for Treatment

Preparing for Treatment

What you should know about treatment
with SPRAVATO™.

What to Expect During Your 
SPRAVATO™ Treatment

Watch this video to learn about the SPRAVATO™ 
treatment process.

 

Getting Started with SPRAVATO™

Working with Your Doctor

Considering SPRAVATO™? The first step is talking to your doctor. Get the facts and decide together if SPRAVATO™ should be part of your overall treatment plan for your treatment-resistant depression.

  • Expect to review your overall medical and depression treatment history. Be sure to tell your doctor if you have a history of abusing prescription or street drugs or a problem with alcohol.
  • Ask if adding SPRAVATO™ to your overall treatment plan might be a next step for you.
  • Do not take SPRAVATO™ if you have had medical conditions such as blood vessel disease (aneurysm), an abnormal connection between your blood vessels (arteriovenous malformation), a history of bleeding in the brain or are allergic to esketamine, ketamine or any of the ingredients in SPRAVATO™.
  • Be sure to tell your doctor if you have any heart (e.g., high blood pressure) or brain problems (e.g., stroke or history of brain injury), liver problems, psychosis, are pregnant or plan to become pregnant or are breastfeeding or planning to breastfeed. You should not take SPRAVATO™ if you are pregnant. You should not breastfeed if you are taking SPRAVATO™.
  • Tell your healthcare provider about all the medicines that you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.
  • For more complete information, please see the Medication Guide.

Planning Your Treatment with SPRAVATO™

SPRAVATO™ cannot be purchased at a pharmacy. To support the safe and appropriate use of SPRAVATO™, it is given at certified SPRAVATO™ treatment centers. This could be a different location than your regular doctor’s office. Your first visit will be a consultation to discuss the details with a healthcare professional at the certified SPRAVATO™ treatment center. If they recommend SPRAVATO™, your doctor will discuss the risks of misuse, abuse, sedation and dissociation with you and enroll you in the SPRAVATO™ Risk Evaluation Mitigation Strategy (REMS) Program. You may start treatment on your next visit.

  • You should not expect treatment on your first visit. A healthcare professional at the certified SPRAVATO™ treatment center will do their own assessment to determine if SPRAVATO™ may be right for you.
  • You will also be able to discuss the REMS Program, insurance matters, scheduling and treatment preparation.
  • You can ask about what to bring with you on treatment days.
 

Treatment Days

Preparing for Treatment

You’ll need to plan for rides to and from the certified SPRAVATO™ treatment center as you should not drive or operate machinery until the day after a treatment session, following a restful sleep. You may want to bring a book, a relaxing playlist or another form of entertainment for the session because your doctor will monitor you for at least two hours after treatment.

Some patients taking SPRAVATO™ may experience nausea or vomiting. You should avoid eating two hours before and drinking liquids 30 minutes before taking SPRAVATO™.

If you take a nasal corticosteroid or nasal decongestant medicine, take these medicines at least one hour before taking SPRAVATO™.

  • At each session, you will be asked about your current depression symptoms and how you are feeling over time.
  • After you administer SPRAVATO™, there will be an observation period of at least two hours, during which you will be allowed to comfortably rest while a healthcare professional monitors you for possible side effects.
  • SPRAVATO™ can cause a temporary increase in your blood pressure that may last for about four hours after taking a dose. Your healthcare provider will check your blood pressure before taking SPRAVATO™ and for at least two hours after you take SPRAVATO™. Tell your healthcare provider right away if you get chest pain, shortness of breath, sudden severe headache, change in vision or seizures after taking SPRAVATO™.
  • Tell your healthcare provider if you have problems thinking or remembering.
  • Tell your healthcare professional if you have any side effect that bothers you or does not go away.
  • Before you leave, talk to your healthcare professional about your plans for the remainder of the day to figure out which activities may or may not be appropriate.
  • Be sure you have accurate contact information for the certified SPRAVATO™ treatment center in case any questions or concerns come up after you leave.
  • Be sure to share your treatment experience with your doctor, who will remain an important part of your care.

How to Use SPRAVATO™ Nasal Spray

You will administer SPRAVATO™ yourself under the supervision of a healthcare professional, who will show you how to use the SPRAVATO™ nasal spray device.

SPRAVATO™ Side Effects

There’s an increased risk of suicidal thoughts and behavior with SPRAVATO™.

Call your doctor right away if you have new or sudden changes in mood, behavior, thoughts or feelings or if you develop suicidal thoughts or actions.

SPRAVATO™ may cause serious side effects including: sedation, dissociation, abuse and misuse, temporary increased blood pressure that may last about four hours after a dose, problems with thinking clearly or bladder problems, such as a frequent or urgent need to urinate, pain when urinating or urinating frequently at night.

The most common side effects that can occur during and after taking SPRAVATO™ include:

  • Dissociation (feeling disconnected from yourself, your thoughts, feelings, space and time)
  • Dizziness
  • Nausea
  • Sedation (sleepiness)
  • Spinning sensation
  • Reduced sense of touch and sensation
  • Anxiety
  • Lack of energy
  • Increased blood pressure
  • Vomiting
  • Feeling drunk
 

Staying on SPRAVATO™

Your First Month and Beyond

You’ll take SPRAVATO™ twice a week for the first month. During the second month, you’ll take it once a week. After that, you’ll take it once a week or once every two weeks. You’ll continue to take an oral antidepressant as prescribed.

  • At each session, you will be asked about your current depression symptoms and how you are feeling over time.
  • After continuing treatment for eight weeks, your healthcare professional may reduce your treatment frequency further, depending on what’s right for you.
  • You should not stop taking SPRAVATO™ without talking to your healthcare professional about your reasons and concerns, and working out an alternative treatment plan with them.

Next:

Patient Stories

Stories of patients who are living with treatment-resistant depression, and their experiences on SPRAVATO™.

Frequently Asked Questions

To support the safe and appropriate use of SPRAVATO™, it is only available at certified SPRAVATO™ treatment centers . Your doctor can refer you to a certified SPRAVATO™ treatment center. Even if your current doctor doesn’t directly treat you with SPRAVATO™, they can and should remain a key partner in helping you with the overall management of your treatment-resistant depression.

On your first visit to a certified SPRAVATO™ treatment center, a healthcare professional will typically do their own assessment to confirm that SPRAVATO™ is right for you. So you shouldn’t expect treatment on your first visit. If SPRAVATO™ is recommended, your doctor will discuss the risks of misuse, abuse, sedation and dissociation with you and enroll you in the SPRAVATO™ Risk Evaluation Mitigation Strategy (REMS) Program. You may start treatment on your next visit. You may also be able to get help with insurance matters, scheduling and treatment preparation.

On treatment days, you will administer SPRAVATO™ nasal spray yourself under the supervision of a healthcare professional. Your healthcare professional will assess your blood pressure prior to and after you administer SPRAVATO™ nasal spray.

After you administer SPRAVATO™ nasal spray yourself, there will be an observation period of at least two hours during which you will be allowed to comfortably rest while a healthcare professional monitors you for possible side effects.

Before you go, talk to your doctor about your plans for the remainder of the day to decide which activities may or may not be appropriate.

You won’t be able to drive or operate machinery that requires you to be completely alert until the next day following a restful sleep. So you'll need to plan for rides on treatment days.

Tell your healthcare professional if you have any side effect that bothers you or does not go away.

If you have high blood pressure, whether treated or not, you should discuss that specifically with your doctor in deciding whether SPRAVATO™ may be right for you. Do not take SPRAVATO™ if you have had medical conditions such as blood vessel disease (aneurysm) or an abnormal connection between your blood vessels (arteriovenous malformation) or a history of bleeding in the brain.

SPRAVATO™ can increase your blood pressure temporarily – for about four hours – so you will have your blood pressure measured at various times, including before and after taking SPRAVATO™.

If your blood pressure is high before using this medicine, your doctor will decide whether to start the medicine or wait until your blood pressure is lower.

Tell your healthcare provider right away if you get chest pain, shortness of breath, sudden severe headache, change in vision or seizures after taking SPRAVATO™.