Preparing for Treatment

Preparing for Treatment

What you should know about treatment

What to Expect During Your 
SPRAVATO™ Treatment

Watch this video to learn about the SPRAVATO™ 
treatment process.


Getting Started with SPRAVATO™

Working with Your Doctor

Considering SPRAVATO™? The first step is talking to your doctor. Get the facts and decide together if SPRAVATO™ should be part of your overall treatment plan for your treatment-resistant depression.

Planning Your Treatment with SPRAVATO™

SPRAVATO™ cannot be purchased at a pharmacy. To support the safe and appropriate use of SPRAVATO™, it is given at certified SPRAVATO™ treatment centers. This could be a different location than your regular doctor’s office. Your first visit will be a consultation to discuss the details with a healthcare professional at the certified SPRAVATO™ treatment center. If they recommend SPRAVATO™, your doctor will discuss the risks of misuse, abuse, sedation and dissociation with you and enroll you in the SPRAVATO™ Risk Evaluation Mitigation Strategy (REMS) Program. You may start treatment on your next visit.


Treatment Days

Preparing for Treatment

You’ll need to plan for rides to and from the certified SPRAVATO™ treatment center as you should not drive or operate machinery until the day after a treatment session, following a restful sleep. You may want to bring a book, a relaxing playlist or another form of entertainment for the session because your doctor will monitor you for at least two hours after treatment.

Some patients taking SPRAVATO™ may experience nausea or vomiting. You should avoid eating two hours before and drinking liquids 30 minutes before taking SPRAVATO™.

If you take a nasal corticosteroid or nasal decongestant medicine, take these medicines at least one hour before taking SPRAVATO™.

How to Use SPRAVATO™ Nasal Spray

You will administer SPRAVATO™ yourself under the supervision of a healthcare professional, who will show you how to use the SPRAVATO™ nasal spray device.

SPRAVATO™ Side Effects

There’s an increased risk of suicidal thoughts and behavior with SPRAVATO™.

Call your doctor right away if you have new or sudden changes in mood, behavior, thoughts or feelings or if you develop suicidal thoughts or actions.

SPRAVATO™ may cause serious side effects including: sedation, dissociation, abuse and misuse, temporary increased blood pressure that may last about four hours after a dose, problems with thinking clearly or bladder problems, such as a frequent or urgent need to urinate, pain when urinating or urinating frequently at night.

The most common side effects that can occur during and after taking SPRAVATO™ include:

  • Dissociation (feeling disconnected from yourself, your thoughts, feelings, space and time)
  • Dizziness
  • Nausea
  • Sedation (sleepiness)
  • Spinning sensation
  • Reduced sense of touch and sensation
  • Anxiety
  • Lack of energy
  • Increased blood pressure
  • Vomiting
  • Feeling drunk

Staying on SPRAVATO™

Your First Month and Beyond

You’ll take SPRAVATO™ twice a week for the first month. During the second month, you’ll take it once a week. After that, you’ll take it once a week or once every two weeks. You’ll continue to take an oral antidepressant as prescribed.


Patient Stories

Stories of patients who are living with treatment-resistant depression, and their experiences on SPRAVATO™.

Frequently Asked Questions